Missouri is home to an impressive array of large corporations that have a significant impact on both the state’s economy and the national business landscape.
With a diverse range of industries represented, these companies play a crucial role in driving growth and providing employment opportunities for thousands of Missourians.
From the sectors of healthcare, transportation, retail, and financial services, the 35 largest companies in Missouri have made their mark in various fields.
Topping the list is Express Scripts Holding Company, a pharmacy benefit manager that provides integrated pharmacy benefit management services to patients across the United States.
This article will explore the 35 largest companies in Missouri, exploring their histories, achievements, and their impact on the state’s economy.
1. Emerson Electric Co.
Background: Emerson Electric Co. is a multinational corporation headquartered in St. Louis, Missouri, specializing in engineering and manufacturing products and providing engineering services for a wide range of industrial, commercial, and consumer markets.
Established in 1890, Emerson has grown into a global leader in innovative technologies, including process management, climate technologies, industrial automation, and more.
Core Industries: Manufacturing, Engineering, Technology
Key Achievements: Emerson Electric Co. has a long history of innovation and excellence, consistently delivering high-quality products and solutions to its customers worldwide.
With a commitment to sustainability and cutting-edge technology, Emerson continues to drive progress and shape the future of industries ranging from energy and healthcare to transportation and agriculture.
2. Express Scripts Holding Co.
Background: Express Scripts Holding Co., based in St. Louis, Missouri, is a pharmacy benefit management organization that provides integrated pharmacy benefit management services.
Including network-pharmacy claims processing, home delivery pharmacy services, specialty pharmacy benefit management, benefit-design consultation, formulary management, and medical and drug data analysis services to manage drug plans for health plans, self-insured employers, and government agencies.
Core Industries: Healthcare, Pharmacy Benefit Management
Key Achievements: Express Scripts Holding Co. is one of the largest pharmacy benefit management organizations in the United States, playing a critical role in managing prescription drug benefits for millions of Americans.
The company’s innovative solutions, technology-driven approach, and commitment to improving healthcare outcomes have earned it a reputation for excellence in the industry.
3. Centene Corporation
Background: Centene Corporation, headquartered in St. Louis, Missouri, is a diversified, multi-national healthcare enterprise that provides a portfolio of services to government-sponsored and commercial healthcare programs, focusing on under-insured and uninsured individuals.
Centene operates health plans and offers a range of health insurance solutions to individuals and families, as well as specialty services such as behavioral health, pharmacy benefits management, and administrative services.
Core Industries: Healthcare, Health Insurance
Key Achievements: Centene Corporation has experienced significant growth and expansion since its founding, becoming one of the largest managed care organizations in the United States.
The company’s mission to improve the health outcomes of its members while reducing healthcare costs has driven innovation and success, earning Centene recognition as a leader in the healthcare industry.
4. O’Reilly Automotive, Inc.
Background: O’Reilly Automotive, Inc., headquartered in Springfield, Missouri, is one of the largest specialty retailers of automotive aftermarket parts, tools, supplies, equipment, and accessories in the United States.
Founded in 1957, O’Reilly operates over 5,600 stores across the country, offering a wide range of products for both professional mechanics and DIY enthusiasts.
Core Industries: Automotive, Retail
Key Achievements: O’Reilly Automotive, Inc. has experienced steady growth and success, expanding its footprint and solidifying its position as a leading provider of automotive parts and accessories.
The company’s commitment to customer service, product quality, and competitive pricing has earned it a loyal customer base and recognition as an industry leader.
5. Edward Jones
Background: Edward Jones is a financial services firm headquartered in St. Louis, Missouri, specializing in providing investment advice and financial planning services to individual investors.
Founded in 1922, Edward Jones operates a network of branch offices throughout the United States and Canada, offering personalized investment solutions and retirement planning services.
Core Industries: Financial Services, Investment Management
Key Achievements: Edward Jones has built a reputation for trustworthiness, integrity, and client-focused service, helping millions of individuals achieve their financial goals over the years.
With a commitment to long-term investing and a personalized approach to wealth management, Edward Jones continues to be a trusted partner for investors seeking financial stability and growth.
6. Monsanto Company
Background: Monsanto Company, based in St. Louis, Missouri, was a leading global provider of agricultural products, including seeds, biotechnology traits, and crop protection chemicals.
Founded in 1901, Monsanto was known for its genetically modified seeds and innovations in agricultural technology aimed at increasing crop yields and enhancing farm productivity.
Core Industries: Agriculture, Biotechnology
Key Achievements: Monsanto Company played a significant role in shaping modern agriculture, developing innovative solutions to address the challenges facing farmers around the world.
The company’s contributions to seed technology, crop protection, and sustainable farming practices have helped improve food security and agricultural sustainability on a global scale.
7. Reinsurance Group of America, Incorporated
Background: Reinsurance Group of America, Incorporated (RGA), headquartered in Chesterfield, Missouri, is one of the largest global life and health reinsurance companies.
Founded in 1973, RGA provides reinsurance, risk management, and financial solutions to insurance companies worldwide, helping them manage their mortality, morbidity, and longevity risks.
Core Industries: Reinsurance, Insurance
Key Achievements: Reinsurance Group of America, Incorporated has established itself as a trusted partner for insurance companies seeking to manage their risk exposure and improve their financial stability.
With a focus on innovation, expertise, and customer service, RGA continues to lead the reinsurance industry and support the growth and success of its clients.
8. Graybar Electric Company, Inc.
Background: Graybar Electric Company, Inc., headquartered in St. Louis, Missouri, is a leading distributor of electrical, communications, and data networking products and related supply chain management and logistics services.
Founded in 1869, Graybar operates more than 260 distribution facilities throughout North America, serving customers in various industries, including commercial, industrial, and government sectors.
Core Industries: Electrical Distribution, Supply Chain Management
Key Achievements: Graybar Electric Company, Inc. has a long history of delivering reliable, high-quality products and services to its customers, helping them meet their electrical and communication needs efficiently and cost-effectively.
The company’s commitment to innovation, sustainability, and customer satisfaction has positioned it as a trusted partner for businesses across a wide range of industries.
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9. Stifel Financial Corp.
Background: Stifel Financial Corp. is a financial services holding company headquartered in St. Louis, Missouri, providing wealth management, investment banking, and institutional brokerage services to clients worldwide.
Founded in 1890, Stifel operates a network of offices across the United States and internationally, offering a comprehensive range of financial solutions to individuals, corporations, and institutional investors.
Core Industries: Financial Services, Investment Banking
Key Achievements: Stifel Financial Corp. has a long-standing reputation for expertise, integrity, and personalized service, helping clients navigate complex financial markets and achieve their investment objectives.
The company’s commitment to putting clients first, along with its extensive industry experience and global reach, has contributed to its success and growth over the years.
10. Ameren Corporation
Background: Ameren Corporation is a Fortune 500 company headquartered in St. Louis, Missouri, and a leading integrated energy company providing electric and natural gas services to customers in Missouri and Illinois.
With a history dating back over a century, Ameren operates a diverse portfolio of power plants, transmission and distribution systems, and natural gas pipelines, serving millions of customers across its service territories.
Core Industries: Energy, Utilities
Key Achievements: Ameren Corporation plays a critical role in delivering reliable, affordable, and sustainable energy to communities across the Midwest, supporting economic growth and development in the region.
The company’s commitment to innovation, environmental stewardship, and customer service has earned it recognition as a leader in the utility industry.
11. Watlow Electric Manufacturing Company
Background: Watlow Electric Manufacturing Company, headquartered in St. Louis, Missouri, is a leading provider of thermal solutions for a wide range of industries, including semiconductor processing, aerospace, automotive, medical equipment, and foodservice.
Founded in 1922, Watlow designs and manufactures electric heaters, temperature controllers, sensors, and thermal management solutions to help customers optimize their processes and improve performance.
Core Industries: Manufacturing, Thermal Solutions
Key Achievements: Watlow Electric Manufacturing Company has a long history of innovation and expertise in thermal technology, developing customized solutions to meet the unique needs of its customers across various industries.
The company’s commitment to quality, reliability, and customer satisfaction has made it a trusted partner for businesses seeking to enhance their manufacturing processes and product performance.
12. Kansas City Southern
Background: Kansas City Southern (KCS) is a transportation holding company headquartered in Kansas City, Missouri, with primary operations in the United States and Mexico.
As a Class I railroad, KCS operates a rail network connecting major markets in the Midwest and South Central United States with key ports in Mexico, facilitating the transportation of freight across North America.
Core Industries: Transportation, Railroads
Key Achievements: Kansas City Southern plays a vital role in facilitating trade and commerce between the United States and Mexico, providing efficient and reliable rail transportation services to businesses across various industries.
With a focus on safety, innovation, and customer service, KCS continues to be a preferred transportation partner for companies seeking to move goods efficiently and cost-effectively.
13. Bunzl Distribution USA, Inc.
Background: Bunzl Distribution USA, Inc., based in St. Louis, Missouri, is a leading distributor of packaging, foodservice, and cleaning supplies to businesses across North America.
As part of the global Bunzl plc group, Bunzl Distribution USA offers a wide range of products and solutions to help customers in various industries meet their packaging, hygiene, and supply chain needs.
Core Industries: Distribution, Packaging
Key Achievements: Bunzl Distribution USA, Inc. has a long history of providing reliable and innovative packaging and supply chain solutions to its customers, helping them streamline operations and enhance efficiency.
The company’s commitment to quality, service, and sustainability has earned it a reputation as a trusted partner for businesses seeking to optimize their supply chain and packaging processes.
14. Post Holdings, Inc.
Background: Post Holdings, Inc., headquartered in St. Louis, Missouri, is a consumer packaged goods holding company that operates through its various subsidiaries in the food and beverage industry.
With a diverse portfolio of brands, including Post Consumer Brands, Michael Foods, Bob Evans Farms, and Weetabix, Post Holdings manufactures and markets a wide range of cereal, egg, dairy, and refrigerated food products.
Core Industries: Food and Beverage, Consumer Goods
Key Achievements: Post Holdings, Inc. is a leader in the food and beverage industry, known for its iconic brands and innovative products that meet the evolving needs of consumers.
The company’s commitment to quality, innovation, and customer satisfaction has enabled it to maintain strong market positions and drive growth in its core categories.
15. Caleres, Inc.
Background: Caleres, Inc., headquartered in St. Louis, Missouri, is a global footwear company that designs, manufactures, and markets a diverse portfolio of footwear brands for women, men, and children.
With a heritage dating back over a century, Caleres operates retail and wholesale channels worldwide, offering a wide range of stylish and comfortable footwear options for every occasion.
Core Industries: Footwear, Fashion
Key Achievements: Caleres, Inc. has a long history of delivering fashionable and comfortable footwear solutions to consumers around the world, earning it a reputation for quality, style, and innovation.
The company’s commitment to designing and manufacturing shoes that combine fashion with function has made it a trusted choice for customers seeking stylish and comfortable footwear options.
16. Schnuck Markets, Inc.
Background: Schnuck Markets, Inc., headquartered in St. Louis, Missouri, is a regional grocery store chain operating over 100 stores in the Midwest.
Founded in 1939, Schnuck Markets offers a wide range of grocery products, including fresh produce, meat, seafood, deli items, bakery goods, and household essentials, as well as pharmacy and floral services.
Core Industries: Retail, Grocery
Key Achievements: Schnuck Markets, Inc. has a long-standing commitment to providing customers with high-quality products, exceptional service, and a pleasant shopping experience.
The company’s focus on community engagement, sustainability, and innovation has helped it maintain strong customer loyalty and establish itself as a trusted grocery retailer in the Midwest.
17. Ralcorp Holdings, Inc.
Background: Ralcorp Holdings, Inc., headquartered in St. Louis, Missouri, was a leading producer of private label food products, including breakfast cereals, snack foods, pasta, sauces, and frozen bakery items.
Acquired by Conagra Brands in 2012, Ralcorp operated as a subsidiary of Conagra, supplying private label and store brand products to retailers, foodservice providers, and other customers.
Core Industries: Food Production, Private Label
Key Achievements: Ralcorp Holdings, Inc. was known for its expertise in private label food production, delivering high-quality products that met the diverse needs of retailers and consumers.
The company’s focus on innovation, efficiency, and customer satisfaction contributed to its success and growth in the private label food industry.
18. Sigma-Aldrich Corporation
Background: Sigma-Aldrich Corporation, based in St. Louis, Missouri, was a leading supplier of research chemicals, biochemicals, lab equipment, and related products and services to scientific and academic institutions, pharmaceutical companies, and biotechnology firms worldwide.
Acquired by Merck KGaA in 2015, Sigma-Aldrich operated as a division of Merck, continuing to provide innovative solutions for scientific research and development.
Core Industries: Chemicals, Life Sciences
Key Achievements: Sigma-Aldrich Corporation was recognized for its extensive product portfolio, technical expertise, and commitment to advancing scientific discovery and innovation.
The company’s products and services played a critical role in supporting research and development efforts across various industries, contributing to advancements in healthcare, agriculture, and technology.
19. Gray Design Group, Inc.
Background: Gray Design Group, Inc., headquartered in St. Louis, Missouri, is a full-service architecture, interior design, and planning firm specializing in commercial, healthcare, education, hospitality, and residential projects.
Founded in 1971, Gray Design Group offers a comprehensive range of design services, from initial concept development to project completion and beyond.
Core Industries: Architecture, Interior Design
Key Achievements: Gray Design Group, Inc. has a reputation for creative design solutions, technical expertise, and personalized service, helping clients bring their vision to life and create spaces that inspire and delight. The firm’s commitment to innovation, sustainability, and client satisfaction has earned it recognition as a leader in the architecture and design industry.
20. Huttig Building Products, Inc.
Background: Huttig Building Products, Inc., based in St. Louis, Missouri, is one of the nation’s largest wholesale distributors of millwork and specialty building products for residential and commercial construction projects.
With a history dating back over 135 years, Huttig operates distribution centers across the United States, offering a wide range of building materials, including doors, windows, roofing, siding, and hardware.
Core Industries: Building Materials, Construction
Key Achievements: Huttig Building Products, Inc. has a long-standing commitment to providing contractors, builders, and remodelers with high-quality building materials and exceptional service.
The company’s extensive product offering, distribution network, and industry expertise have made it a trusted partner for customers seeking reliable and innovative solutions for their construction projects.
21. UniGroup, Inc.
Background: UniGroup, Inc., headquartered in Fenton, Missouri, is a leading provider of relocation and transportation services, including household goods moving, corporate relocation, logistics, and storage solutions.
As the parent company of United Van Lines and Mayflower Transit, UniGroup operates a network of agents and affiliates across the United States and around the world, serving residential and commercial customers.
Core Industries: Relocation, Transportation
Key Achievements: UniGroup, Inc. has a long history of helping individuals, families, and businesses navigate the complexities of moving and relocation.
The company’s commitment to quality, reliability, and customer satisfaction has made it a trusted choice for customers seeking seamless and stress-free moving and transportation services.
22. Enterprise Holdings, Inc.
Background: Enterprise Holdings, Inc., headquartered in St. Louis, Missouri, is a global leader in car rental, leasing, and transportation solutions.
With a portfolio of brands including Enterprise Rent-A-Car, National Car Rental, and Alamo Rent A Car, Enterprise Holdings operates a network of thousands of locations worldwide, serving customers in over 100 countries.
Core Industries: Transportation, Car Rental
Key Achievements: Enterprise Holdings, Inc. is known for its commitment to customer service, innovation, and sustainability, offering a wide range of transportation solutions to meet the needs of travelers and businesses around the world.
The company’s global presence, diverse fleet of vehicles, and industry-leading technology have made it a preferred choice for customers seeking reliable and convenient transportation options.
23. Peabody Energy Corporation
Background: Peabody Energy Corporation, headquartered in St. Louis, Missouri, is the largest private-sector coal company in the world, engaged in the mining, sale, and distribution of coal and related products.
With a presence in major coal-producing regions around the globe, Peabody Energy supplies coal to electric utilities, steel producers, and industrial customers worldwide.
Core Industries: Energy, Mining
Key Achievements: Peabody Energy Corporation has a long history of providing reliable and affordable coal products to customers in various industries, supporting economic growth and development around the world.
The company’s commitment to safety, environmental stewardship, and innovation has helped it maintain its position as a leader in the global coal industry.
24. RGA Reinsurance Company
Background: RGA Reinsurance Company, headquartered in Chesterfield, Missouri, is a subsidiary of Reinsurance Group of America, Incorporated, specializing in providing life and health reinsurance solutions to insurance companies worldwide.
With a focus on risk management, underwriting expertise, and financial solutions, RGA Reinsurance Company helps clients manage their mortality, morbidity, and longevity risks.
Core Industries: Reinsurance, Insurance
Key Achievements: RGA Reinsurance Company is known for its innovation, financial strength, and client-focused approach to reinsurance, helping insurance companies navigate complex risk environments and achieve their business objectives.
The company’s commitment to excellence, integrity, and long-term partnerships has made it a trusted reinsurance partner for insurers around the world.
25. The Doe Run Company
Background: The Doe Run Company, headquartered in St. Louis, Missouri, is a leading producer of lead, copper, and zinc concentrates, as well as related metals and chemicals.
With operations in Missouri, Washington, and Arizona, Doe Run is one of the largest integrated lead producers in the Western Hemisphere, supplying essential metals for a wide range of industries.
Core Industries: Mining, Metals
Key Achievements: The Doe Run Company has a long history of responsible mining and sustainable resource development, contributing to the economic growth and vitality of the communities where it operates.
The company’s commitment to safety, environmental stewardship, and community engagement has earned it recognition as a leader in the mining industry.
26. LMI Aerospace, Inc.
Background: LMI Aerospace, Inc., based in St. Charles, Missouri, is a leading supplier of structural assemblies, kits, and components for the aerospace and defense industries.
With a focus on precision engineering, manufacturing, and assembly, LMI Aerospace provides integrated solutions to aircraft manufacturers and defense contractors worldwide.
Core Industries: Aerospace, Defense
Key Achievements: LMI Aerospace, Inc. is known for its expertise in complex aerospace structures and assemblies, delivering high-quality products and solutions that meet the stringent requirements of the aerospace and defense industries.
The company’s commitment to innovation, quality, and customer satisfaction has made it a trusted partner for leading aerospace manufacturers and defense contractors.
27. R.P. Lumber Co., Inc.
Background: R.P. Lumber Co., Inc., headquartered in Edwardsville, Illinois, is a leading retail and wholesale supplier of lumber, building materials, and hardware products.
With over 70 locations across Illinois, Missouri, and Kentucky, R.P. Lumber serves contractors, builders, and homeowners, offering a wide range of products for construction, remodeling, and home improvement projects.
Core Industries: Building Materials, Retail
Key Achievements: R.P. Lumber Co., Inc. has a long history of providing quality products, competitive pricing, and exceptional customer service to its customers, helping them achieve their construction and home improvement goals.
The company’s commitment to integrity, reliability, and community engagement has made it a trusted partner for contractors and homeowners alike.
28. McBride & Son Homes, Inc.
Background: McBride & Son Homes, Inc., based in Chesterfield, Missouri, is one of the largest homebuilders in the Midwest, specializing in the construction of single-family homes, townhomes, and condominiums.
With a focus on quality craftsmanship, innovative design, and customer satisfaction, McBride & Son Homes has built a reputation for excellence in the homebuilding industry.
Core Industries: Real Estate, Construction
Key Achievements: McBride & Son Homes, Inc. has a long history of delivering high-quality homes and exceptional value to its customers, helping them achieve their dream of homeownership.
The company’s commitment to innovation, sustainability, and customer service has earned it recognition as a leader in the residential construction market.
29. Murphy Company
Background: Murphy Company, headquartered in St. Louis, Missouri, is one of the nation’s largest mechanical contracting firms, specializing in HVAC (heating, ventilation, and air conditioning), plumbing, piping, and industrial process systems.
With a legacy dating back to 1907, Murphy Company provides design-build, construction, and maintenance services to commercial, industrial, and institutional clients.
Core Industries: Construction, Mechanical Contracting
Key Achievements: Murphy Company has a reputation for excellence in mechanical contracting, delivering innovative solutions and superior craftsmanship to its clients across a wide range of industries.
The company’s commitment to safety, quality, and customer satisfaction has made it a trusted partner for businesses seeking reliable and efficient mechanical systems.
30. Suddenlink Communications
Background: Suddenlink Communications, headquartered in St. Louis, Missouri, is a leading provider of broadband internet, cable television, and digital phone services to residential and business customers in the United States.
With a network spanning 16 states, Suddenlink offers high-speed internet access, advanced digital television programming, and voice communication services to millions of subscribers.
Core Industries: Telecommunications, Media
Key Achievements: Suddenlink Communications is known for its commitment to delivering reliable, high-quality communication services to its customers, enhancing connectivity and entertainment experiences in communities across the country.
The company’s focus on innovation, customer service, and community engagement has helped it maintain strong market positions and drive growth in the telecommunications industry.
31. Midwest Products Group
Background: Midwest Products Group, headquartered in Fenton, Missouri, is a leading manufacturer and distributor of building products for residential and commercial construction projects.
With a focus on quality, innovation, and customer service, Midwest Products Group offers a comprehensive range of construction materials, including lumber, siding, trim, decking, and fencing.
Core Industries: Building Materials, Manufacturing
Key Achievements: Midwest Products Group has a long history of providing high-quality building products and solutions to contractors, builders, and homeowners, helping them achieve their construction goals efficiently and cost-effectively.
The company’s commitment to innovation, sustainability, and customer satisfaction has made it a preferred supplier for construction projects of all sizes.
32. Mid-America Logistics, LLC
Background: Mid America Logistics, LLC, based in Fenton, Missouri, is a leading third-party logistics provider specializing in transportation management, freight brokerage, and supply chain solutions.
With a network of carriers and logistics partners across North America, Mid America Logistics offers customized transportation solutions to meet the unique needs of its customers.
Core Industries: Logistics, Transportation
Key Achievements: Mid America Logistics, LLC is known for its expertise in logistics and transportation management, helping businesses optimize their supply chain operations and reduce transportation costs.
The company’s commitment to innovation, reliability, and customer service has earned it a reputation as a trusted logistics partner for companies across various industries.
33. Nooter Construction Company
Background: Nooter Construction Company, headquartered in St. Louis, Missouri, is a leading provider of construction, maintenance, and repair services for industrial facilities and infrastructure projects.
With a focus on safety, quality, and efficiency, Nooter Construction offers a wide range of construction and engineering solutions to clients in the power generation, refining, chemical, and manufacturing industries.
Core Industries: Construction, Engineering
Key Achievements: Nooter Construction Company has a long history of delivering complex construction projects safely, on time, and within budget, earning it recognition as a leader in the industrial construction sector.
The company’s expertise in engineering, fabrication, and construction management has made it a preferred contractor for clients seeking reliable and efficient solutions for their industrial facilities.
34. Graybar Electric Co. Inc.
Background: Graybar Electric Co. Inc., headquartered in Clayton, Missouri, is a leading distributor of electrical, communications, and data networking products and related supply chain management and logistics services.
With a network of more than 260 distribution facilities across North America, Graybar serves customers in various industries, including commercial, industrial, and government sectors.
Core Industries: Electrical Distribution, Supply Chain Management
Key Achievements: Graybar Electric Co. Inc. has a long history of providing reliable and innovative electrical products and solutions to its customers, helping them meet their infrastructure and technology needs efficiently and cost-effectively.
The company’s commitment to quality, service, and sustainability has made it a trusted partner for businesses seeking dependable and integrated supply chain solutions.
35. US Bankruptcy Court
Background: The US Bankruptcy Court, headquartered in St. Louis, Missouri, is a federal court that handles bankruptcy cases filed by individuals and businesses across the Eastern District of Missouri.
As part of the federal judiciary system, the US Bankruptcy Court ensures fair and efficient resolution of bankruptcy proceedings, providing debtors and creditors with legal protection and oversight.
Core Industries: Legal, Judiciary
Key Achievements: The US Bankruptcy Court plays a critical role in administering bankruptcy cases and facilitating the restructuring and resolution of financial difficulties for individuals and businesses.
The court’s commitment to fairness, impartiality, and due process ensures that bankruptcy proceedings are conducted in accordance with the law and the principles of justice.
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Conclusion
In conclusion, Missouri boasts a diverse array of industries and companies that contribute significantly to the state’s economy and beyond.
From global leaders in engineering and technology like Emerson Electric Co. and Express Scripts Holding Co. to prominent players in healthcare such as Centene Corporation, the state’s business landscape is rich and varied.
Additionally, Missouri is home to major players in sectors like manufacturing, transportation, construction, and telecommunications, reflecting its position as a hub for innovation and commerce.
The achievements and contributions of these 35 companies underscore Missouri’s importance in the national and global business arena, showcasing the state’s resilience, ingenuity, and commitment to excellence.
